Future of Psilocybin Research and Development

Known Amounts of Purposefully Chosen Psilocybin Derivatives

  • For the past 50 years, psilocybin (the active compound in “magic mushrooms”) has been viewed as a dangerous drug with no therapeutic value.
  • Meanwhile, the pharmaceutical industry has failed to create good drugs for treating mood disorders, such as depression, anxiety, compulsive disorders, and addiction. The leading products have long onset times, severe side-effects, and poor efficacy.
  • Failure in the pharmaceutical industry, combined with a lack of research and development in the psilocybin field, has resulted in a longstanding unmet need for products that effectively treat mood disorders without terrible side-effects.
  • Recent research indicates that psilocybin is safe and medically useful.
  • Pure synthetic psilocybin is available in extremely limited supply, making it extremely expensive for researchers.
  • However, the pharmacology of pure synthetic psilocybin is different from mushrooms because mushrooms have a combination of multiple psilocybin derivatives.  See Entourage Effect.
entourage effect
Magic Mushrooms contain multiple active ingredients, which synergistically create the observed properties. This is also called the “Entourage Effect.”  By cracking Nature’s code, humans can manufacture consistent and reliable products that also provide the synergistic effects achieved by combining the right combination of ingredients.
  • Future psilocybin products will include multiple known ingredients in known amounts.
  • The next generation of psilocybin products will optimize the “entourage effect” attained by using multiple active components, while also ensuring that those components are formulated in consistent and reliable amounts.
Research on the Chemistry, Biology, and Neuropsychology of Psilocybin

Journal of Psilocybin Science