Chemical & Engineering News Discusses Entourage Effect

A July 21, 2019 article in the American Chemical Society’s Chemical & Engineering News by Britt E. Erickson discussed the importance of the Entourage Effect in cannabis health.

Like magic mushroom fruiting bodies, cannabis plant material includes multiple active ingredients (cannabinoids, terpenoids, and other “minor components”), which modulate its biological and clinical properties. Often, taking a combination of those active ingredients is better than taking only one of them. Similar to how natural mushrooms offer benefits over pure psilocybin, full spectrum cannabis products (or formulations) provide benefits over single active ingredients, like pure THC or pure CBD. See also Psilocybin Formulations. See Cannabis v Magic Mushrooms Analogy.

From the article:

“Whole-plant extracts not only are more effective but also have fewer side effects than pure CBD at higher doses, Russo says. The bottom line, he says, is that “whole-cannabis extracts are going to have an advantage over pure compounds in almost every instance.”

Ms. Erickson’s article is consistent with Rolling Stone’s indication that the future of the cannabis industry will come from formulations. 

3 thoughts on “Chemical & Engineering News Discusses Entourage Effect

  1. Jim Reply

    I have been stating this for two decades. Indeed Russo was heavily influenced in his entourage hypothesis by those of us who pioneered medicinal use beyond palliative care.
    The single bullet methodology is a pharmaceutical fantasy that has mimicked success and brought huge profit but it is not the future of botanical medicine.
    Whole plant products and breeding plants for tuned complexes of actives is the future.
    Understanding the gestalt effect of botanical pharmacology will be a leap forward in understanding our own physiology

    • Staff Scientist Post authorReply

      Thanks for your comment Jim. Yes, there seems to be a tremendous amount of untapped potential here!
      Could you please point us to some examples of where you have been discussing this topic for the past two decades. It would be great to reference your work and give appropriate credit.

  2. jeff Reply

    Penis Envy (PE) magic mushrooms are a quite unique variety of Psilocybe cubensis mushroom, with an extremely interesting history. This “strain” is decidedly the most potent Psilocybe Cubensis magic mushroom variety, however unfortunately due to the legality surrounding Shrooms, there are no publicly accessible test results to confirm exactly how much more potent this variety is, or if differing ratios of psychotropic compounds are present (which also has notable effect on the experience).


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