Formulating New “Magic Mushroom” Compositions

Formulating New Compositions Using Molecules in Magic Mushrooms

Mother nature provides the world with magic mushrooms.  Those naturally occurring mushrooms are products of nature. For example, in some parts of the world, cultivated mushrooms are available for sale.  At one point, so-called “smart shops” in Amsterdam sold containers of fresh mushrooms.  Those cultivated mushrooms were truly “products of nature.”

Fresh magic mushrooms available for sale. These unaltered products of nature can be taken as-is or used to make refined products.

Naturally occurring psychoactive mushrooms are known to provide numerous benefits when taken in their unaltered form.  (Eating fresh or dried mushroom fruiting bodies).  Additionally, naturally occurring mushrooms can be processed into products of human ingenuity.  The cartoon below shows a high level process for extracting and isolating molecules from magic mushrooms.

Naturally occurring psychoactive mushrooms can be extracted with a solvent to eliminated the insoluble structural material of the mushroom. That extract can be further processed, to separate out the molecules present in the extract — resulting in a collection of isolated individual molecules.

Extracting Components from Mushrooms

Mushroom extracts can be made as follows: (1) treating mushroom material with a suitable solvent;  (2) filtering away the insoluble mushroom material; and then (3) optionally evaporating the solvent to concentrate the extract.

The first two steps (adding a solvent and then filtering the insoluble material) are familiar to anyone who has made a mushroom tea or tincture.  In the case of making mushroom tea, the mushrooms are extracted with hot water, then filtered (e.g., with a coffee filter) to remove the insoluble material.  The resulting tea is a mushroom extract.

Mushroom tea is one example of a mushroom extract.

Separating Individual Molecules from Mushroom Extract

Typically extracting a mushroom with a solvent provides an extract having many different molecules.  The common property of those molecules is that they are soluble in the extraction solvent.  For example, the mushroom tea described above has many different molecules; all of those molecules are soluble in hot water.  The extraction step serves to separate (A) molecules that are soluble from (B) molecules that are not soluble.

Extracts can be further purified using a variety of techniques.  For example, the extract can be further extracted with different solvents to afford additional selectivity based on solubility.  Or, the components of the extract can be separated by distillation, chromatography, or crystallization.  With each subsequent step, some components are removed from the extract.  As a result, the material extracted from the mushrooms becomes increasingly pure–until only one molecule is present.

Individual purified molecules can either be used alone– or in combination with other molecules to make formulated combination products.  See also Psilocybin Chemistry.

Formulating New Magic Mushroom Compositions

New compositions can be created by formulating purified molecules into stable products or new combinations.  For example, formulating precise amounts of purified psilocybin with stabilizers and/or antioxidants could provide products having clean, stable, and consistent ingredients.

Purposely formulating products would eliminate existing problems with contamination, degradation, variable concentrations of active ingredients, and variable effects.

This advance would also probably eliminate side effects (e.g., Wood Lover Paralysis).

Precisely formulated products would also improve “microdosing” by providing access to accurate doses.  See Microdosing.

Furthermore, the different psilocybin derivatives could be purposefully chosen to provide particular effects.  For example, maybe adding unusually high amounts of Aeruginascin to a psilocybin formulation creates unexpected activity at serotonin receptors.  Or, perhaps a particular combination of baeocystin and psilocin creates a sought after effect for the user.  (We have no idea because the psilocybin arts focus on magic mushrooms instead of magic molecules.)

Lastly, those psilocybin derivatives could be combined with other psychoactive molecules to amplify benefits, reduce side effects.  For example, perhaps existing pharmaceutical drugs for treating mood disorders can be improved by concurrently administering small amounts of psilocybin.

3 thoughts on “Formulating New “Magic Mushroom” Compositions

  1. William Fitzgerald

    I took golden teacher and hairy buffalo and it cured my PTSD depression add by polor addition all the noise is gone

  2. Mike girard

    What solvent is used? Distillation under vacuum? Titration to crystallization? What acid/base is used to drop the crystals? Is this temp sensitive? Thanks.

    • Staff Scientist Post author

      Hi Mike – There are a variety of solvent systems that work well for chromatography (either flash or prep TLC). Likewise, there are a variety of crystallization procedures that provide pure molecules. For psilocybin, the most popular crystallization solvent appears to be methanol or water/methanol mixtures. And for methanol, slow evaporation or cooling saturated solutions seems to provide clean, crystalline material.
      At a high level, everything is temperature sensitive — both in terms of unwanted degradation and also solubility (which would effect your ability to selectively crystalize materials).
      We are explicitly avoiding advocating for particular “manufacturing” procedures. However, we will work to summarize the literature methods soon.

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