Magic Mushroom Bluing Reaction – Request for Research Proposals

Bluing Reaction – Request for Proposals

Bluing (or blue bruising) is one of the most famous features of psilocybin containing mushrooms, aka “magic mushrooms.”  See article on bluing reaction.  In short, “magic mushrooms” exhibit a bluing phenomenon when they are bruised or damaged.  This color change is universally assumed to arise from psilocybin/psilocin.  For example, the oxidation and/or degradation of psilocin.  But, no one has proven this hypothesis or studied the chemical mechanism.

According to Paul Stamets in Psilocybin Mushrooms of the World, “No one, to date, has been able to pinpoint the chemical structure of the bluing compound.

Our current understanding of the psilocybin bluing reaction provides one example of the our community’s unmet need for better psilocybin chemistry.

Request for Proposals for Elucidating the Psilocybin Bluing Reaction

Psilocybin Technology and The Journal of Psilocybin Science have acquired funding commitments for investigating the psilocybin bluing reaction.  If you are interested in studying this reaction, please contact us regarding submitting a research proposal.  Research proposals should include the following:

  1. Brief Overview of Research
  2. Your Organization’s Background
  3. Project Goals
  4. Scope of Work & Deliverables
  5. Timeline for Completing Work
  6. Technical Capabilities of Your Organization
  7. Principal Point of Contact
  8. Itemized Budget
  9. Examples of Previous Work Demonstrating Capabilities

Research proposals that involve experiments with magic mushrooms and/or psilocybin derivatives should also include a statement explaining your organization’s clearance to work with those materials within the territory where the research will be performed.

The deadline for submitting a proposal is November 1st, 2018.  Funding decisions will be made before January 1st, 2018.

Some References Relevant to Psilocybin Bluing Reaction

  1. GARTZ J., 1991- Quantitative Bestimmung der Indolderivate von Psilocybe semilanceata (Fr.) Kumm. Biochem. Physiol. Pflanzen 181: 113-128.
  2. GARTZ J., 1987- Variation der Alkaloidmengen in Fruchtkörpern von Inocybe aeruginascens. Planta Med. 48: 539-541.
  3. GARTZ J., 1989- Analyse der Indolderivate in Fruchtkörpern und Myzelien von Panaeolus subalteatus (Berk. & Br.) Sacc. Biochem. Physiol. Pflanzen 184: 171-178.
  4. Stamets, P. (1996). Psilocybin mushrooms of the world: An identification guide. Berkeley, Calif: Ten Speed Press.
  5. Rutgers University General Chemistry example.
  6. Wikipedia “Copper” (see coordination chemistry).

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