Bluing Reaction – Request for Proposals
Bluing (or blue bruising) is one of the most famous features of psilocybin containing mushrooms, aka “magic mushrooms.” See article on bluing reaction. In short, “magic mushrooms” exhibit a bluing phenomenon when they are bruised or damaged. This color change is universally assumed to arise from psilocybin/psilocin. For example, the oxidation and/or degradation of psilocin. But, no one has proven this hypothesis or studied the chemical mechanism.
According to Paul Stamets in Psilocybin Mushrooms of the World, “No one, to date, has been able to pinpoint the chemical structure of the bluing compound.“
Our current understanding of the psilocybin bluing reaction provides one example of the our community’s unmet need for better psilocybin chemistry.
Request for Proposals for Elucidating the Psilocybin Bluing Reaction
Psilocybin Technology and The Journal of Psilocybin Science have acquired funding commitments for investigating the psilocybin bluing reaction. If you are interested in studying this reaction, please contact us regarding submitting a research proposal. Research proposals should include the following:
- Brief Overview of Research
- Your Organization’s Background
- Project Goals
- Scope of Work & Deliverables
- Timeline for Completing Work
- Technical Capabilities of Your Organization
- Principal Point of Contact
- Itemized Budget
- Examples of Previous Work Demonstrating Capabilities
Research proposals that involve experiments with magic mushrooms and/or psilocybin derivatives should also include a statement explaining your organization’s clearance to work with those materials within the territory where the research will be performed.
The deadline for submitting a proposal is November 1st, 2018. Funding decisions will be made before January 1st, 2019.
Some References Relevant to Psilocybin Bluing Reaction
1. Gartz J. Analyse der Indolderivate in Fruchtkörpern and Mycelien von Panaeolus subalteatus (Berk. & Br.) Sacc. Biochemie und Physiologie der Pflanzen. 1989;184(1-2):171-178. doi:10.1016/S0015-3796(89)80139-8
2. Gartz J. Quantitative Bestimmung der Indolderivate von Psilocybe semilanceata (Fr.) Kumm. Biochemie und Physiologie der Pflanzen. 1986;181(2):117-124. doi:10.1016/S0015-3796(86)80079-8
3. Gartz J. Variation der Alkaloidmengen in Fruchtkörpern von Inocybe aeruginascens. Planta medica. 1987;53(06):539-541. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2006-962805.
4. Copper. In: Wikipedia. 2018. https://en.wikipedia.org/w/index.php?title=Copper&oldid=859028008. Accessed September 28, 2018. See section on Coordination Chemistry.
5. Copper Amine. GenChem – Rutgers University. http://genchem.rutgers.edu/cuNH3.html. Accessed September 28, 2018.