Phenylethylamine – Overlooked Active in Magic Mushrooms


Psychoactive mushrooms have recently received considerable attention in the popular news media.  For the most part, reports focus on either (a) “magic mushrooms” or (b) the molecule psilocybin.  (A few articles point out that psilocin is actually the active molecule.)

Magic mushrooms have multiple other active components.  One of them is called phenethylamine (“PEA”).  These molecules are almost never acknowledged.  And, they are probably involved the pharmacology of magic mushrooms.

Phenethylamine is Present in Magic Mushrooms

Phenethylamine acts as a central nervous system stimulant in humans. Phenethylamine is similar to amphetamine in its action.  It causes the release of norepinephrine and dopamine.

Phenethylamine is produced by a wide range of species throughout the plant and animal kingdoms, including humans and fungi, such as magic mushrooms.

Phenethylamine has been quantifiably measured in multiple collections of psychoactive mushrooms.  See Beck, O. et al.  J Anal Toxicol. 1998 Jan-Feb; 22(1):45-9.  (“Presence of phenylethylamine in hallucinogenic Psilocybe mushrooms: possible role in adverse reactions.”

Phenethylamine Shows Need for Improving Psilocybin Chemistry

The presence of phenylethylamine in “magic mushrooms” shows why it is important to distinguish mushrooms from the collection of molecules inside those mushrooms.

The path to better psilocybin products will begin by treating magic mushrooms as collections of magic molecules.  Even in the most potent “magic” mushrooms, psilocybin is only present in about 1-2% by mass. This means that 98-99% of that mushroom is composed of other molecules — like phenylethylamine.  Molecules like phenylethylamine are psychoactive and likely modulate the effects of psilocybin and/or psilocin.

As evidenced by the prevalence of “magic mushroom” language, psilocybin technology is presently viewed from a mycologist’s perspective.  That perspective is essential to cultivating and/or identifying magic mushrooms.  However, future advances in treating conditions (like anxiety and depression) will require viewing these mushrooms from a chemical perspective.


2 thoughts on “Phenylethylamine – Overlooked Active in Magic Mushrooms

    • Staff Scientist Post author

      Did you look at the citation in the post?

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