Psilocybin “Microdosing” State of the Art — Unknown Molecules & Lack of Precise Dosing
Our staff recently published a few articles regarding “microdosing,” especially microdosing psilocybin. We have received many insightful comments. Below is a summary of the state of the art as of April 24, 2018.
- DEFINITION – Generally speaking, the term “microdosing” means taking a “sub threshold” quantity of a substance known for causing “psychedelic” experiences when taken in doses above the accepted “threshold” amount.
- DOSE – Experts on microdosing recommend taking about 1/10th of a “psychedelic” dose. For psilocybin, this means taking anywhere from a few tenths of a milligram to several milligrams of psilocybin.
- ADMINISTRATION – Presently, psilocybin users administer psilocybin by eating “magic mushrooms.” Accordingly, users administer psilocybin by estimating the concentration of psilocybin in a collection of mushrooms.
- VARIABILITY – Psilocybin mushrooms are highly variable in both chemical composition and chemical concentration.
- STANDARD – The state of the art for microdosing psilocybin currently accepts significant variability in both the chemicals administered and the amount that is taken.
** Does anyone disagree with the above facts? Please comment.
Taking precise and accurate amounts of any substance requires having a dosage form with a known quantity of a known chemical. For example, taking a tablet having 1.0 mg of psilocybin as the only active ingredient. Accordingly, psilocybin “microdosing” technology would benefit from reliable dosage formulations that provide a precise amount of psilocybin. See Psilocybin Chemistry.